LL-37

Name: LL-37
SKU: 5002
Availability: InStock

$177

21 people are viewing this right now

6 products sold in last 2 hours

Selling fast! Over 6 people have this in their carts

CAS NO: 154947-66-7
Molecular Formula: C205H340N60O53
Molecular Weight: 4493.32
Appearance: white powder
Storage: 2-8°
Purity: ≥99

BULK QUANTITY DISCOUNT:

2-4 vials – 5% OFF

5-9 vials – 10% OFF

10-14 vials – 12% OFF

15-20 vials – 15% OFF

8 in stock

Title	Range	Discount
Bulk discount	3	3%
Bulk discount	4 – 5	4%
Bulk discount	6 – 9	6%
Bulk discount	10 – 14	10%
Bulk discount	15 +	15%

Estimated Delivery : Up to 3 business days
Free Shipping & Returns : On all orders over $300

Guaranteed Safe And Secure Checkout

Description
Reviews(0)

LL-37 is a cationic antimicrobial peptide (AMP) that is part of the cathelicidin family, playing a crucial role in the innate immune system. Derived from the precursor protein hCAP18, LL-37 is produced by various cell types, including neutrophils, epithelial cells, and immune cells. It exhibits a broad spectrum of antimicrobial activity against bacteria, viruses, and fungi by disrupting their cell membranes. Beyond its antimicrobial properties, LL-37 is also involved in modulating inflammation, promoting wound healing, and influencing adaptive immune responses. It can attract immune cells to sites of infection and enhance the production of cytokines, contributing to host defense.

LL-37 Peptide Benefits: Antimicrobial Power & Immune Support

LL-37 is the only human cathelicidin antimicrobial peptide, playing a pivotal role in innate immunity, inflammation control, and tissue repair. Below is a scientifically grounded, SEO-aware summary of key research-backed benefits—each supported with PubMed links.

1. Broad-Spectrum Antimicrobial Activity

LL-37 directly disrupts the membranes of bacteria, fungi, and enveloped viruses. It also helps neutralize toxic components like LPS, supports biofilm disruption, and enhances microbial clearance.
Comprehensive review of LL-37’s multifaceted antimicrobial effects [oai_citation:0‡Reddit](https://www.reddit.com/r/healthwithjessicalana/comments/18qfuje/ll37_peptide_a_multifaceted_peptide/?utm_source=chatgpt.com)
LL-37 inhibits macrophage stimulation by LPS, protecting against endotoxemia [oai_citation:1‡PubMed](https://pubmed.ncbi.nlm.nih.gov/12244186/?utm_source=chatgpt.com)

2. Immunomodulatory & Anti-inflammatory Effects

LL-37 modulates immune cell functions—dampening excessive inflammation while enhancing antimicrobial responses. It regulates neutrophil activation, ROS production, cytokine release, and chemokine expression.
LL-37 shapes neutrophil responses and inflammatory mediator release [oai_citation:2‡PubMed](https://pubmed.ncbi.nlm.nih.gov/20140902/?utm_source=chatgpt.com)
LL-37 in SARS-CoV-2 infection: antiviral activity, inflammation control, and tissue protection [oai_citation:3‡PubMed](https://pubmed.ncbi.nlm.nih.gov/35634307/?utm_source=chatgpt.com)
LL-37 reduces pyroptosis in sepsis models and improves survival [oai_citation:4‡PubMed](https://pubmed.ncbi.nlm.nih.gov/26746575/?utm_source=chatgpt.com)

3. Wound Healing, Angiogenesis & Biofilm Disruption

LL-37 accelerates wound repair via keratinocyte and fibroblast activation, angiogenesis, and extracellular matrix remodeling. It also combats resilient biofilms in polymicrobial wound infections.
Anti-biofilm and wound-healing benefits of LL-37 in infected wounds [oai_citation:5‡Frontiers](https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2013.00143/full?utm_source=chatgpt.com)

4. Host Barrier Integrity & Endothelial Function

LL-37 influences endothelial cell behavior, strengthening vascular barrier function—a key in controlling inflammation and maintaining tissue homeostasis.
LL-37 modulates endothelial stiffness and permeability via P2X7 signaling [oai_citation:6‡PubMed](https://pubmed.ncbi.nlm.nih.gov/20943960/?utm_source=chatgpt.com)

5. Dual Roles in Cancer & Tissue Signaling

LL-37 shows complex, tissue-specific roles in tumor biology—it may promote or suppress CANC depending on context. It also participates in skin and epithelial regeneration through cellular signaling pathways.
Emerging roles of LL-37 in immunity, CANC, and tissue regulation [oai_citation:7‡PMC](https://pmc.ncbi.nlm.nih.gov/articles/PMC2930073/?utm_source=chatgpt.com)

6. Overview: LL-37 in Innate Immunity

As the primary human-derived cathelicidin, LL-37 is synthesized by immune and epithelial cells (like neutrophils, macrophages, and skin cells). It is rapidly activated from its precursor (hCAP-18) and contributes to immune defense, inflammation regulation, and wound repair.
Overview of LL-37 origin, mechanism, and functions in human immunity [oai_citation:8‡en.wikipedia.org](https://en.wikipedia.org/wiki/Cathelicidin_antimicrobial_peptide?utm_source=chatgpt.com)

Summary Table

Benefit	LL-37 Peptide
Antimicrobial Defense	Broad-spectrum action—bacteria, fungi, viruses, biofilms
Immune Modulation	Balances inflammatory response, enhances pathogen clearance
Wound Healing & Biofilm Disruption	Boosts cell migration, angiogenesis, fights resilient infections
Barrier Integrity	Improves endothelial health and tissue stability
Cancer & Regeneration	Context-dependent effects in CANC; supports tissue repair